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Biochemical Systematics and Ecology
Chemical constituents from the root bark of Ozoroa insignis2009 •
2003 •
The crude methanol bark extract of the Zimbabwean medicinal plant, Ozoroa insignis, showed in-vitro cytotoxic activity against Hep-G2 (human hepatocellular carcinoma), MDA-MB-231 (human mammary adenocarcinoma), and 5637 (human primary bladder carcinoma). Bioactivity-directed chromatographic separation led to isolation of anacardic acid and ginkgoic acid as the cytotoxic components.
Ozoroa insignis Del. is an ethnobotanical plant widely used in traditional medicine for various ailments, including schistosomiasis, tapeworm, and hookworm infections. From the so far not investigated fruits of Ozoroa insignis, the anthelmintic principles could be isolated through bioassay-guided isolation using Caenorhabditis elegans and identified by NMR spectroscopic analysis and mass spectrometric studies. Isolated 6-[8(Z)-pentadecenyl] anacardic (1), 6-[10(Z)-heptadecenyl] anacardic acid (2), and 3-[7(Z)-pentadecenyl] phenol (3) were evaluated against the 5 parasitic organisms Schistosoma mansoni (adult and newly transformed schistosomula), Strongyloides ratti, Heligmosomoides polygyrus, Necator americanus, and Ancylostoma ceylanicum, which mainly infect humans and other mammals. Compounds 1–3 showed good activity against Schistosoma mansoni, with compound 1 showing the best activity against newly transformed schistosomula with 50% activity at 1µM. The isolated compounds were a...
Revista Brasileira de Ciência, Tecnologia e Inovação
Chemical profile of the twigs of Ozoroa obovata by HPLC-MS-ESI and antimicrobial activityPharmaceutical Biology
Activity of 6-Pentadecylsalicylic Acid from Ozoroa insignis Against Marine Crustaceans2002 •
Journal of Agricultural and Food Chemistry
Synthesis and Biological Evaluation of New Ozonides with Improved Plant Growth Regulatory Activity2009 •
South African Journal of Botany
Cytotoxic, antimicrobial, antioxidant, antilipoxygenase activities and phenolic composition of Ozoroa and Searsia species (Anacardiaceae) used in South African traditional medicine for treating diarrhoea2014 •
Tetrahedron Letters
Antiproliferative compounds from Ocotea macrocarpa from the Madagascar dry forest12015 •
Journal of Pharmaceutical Sciences
Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials2006 •
Chemical stability of a new class of ozonide (1,2,4 trioxolanes) antimalarial compounds was investigated. The effects of pH, ionic strength, dielectric constant and cyclodextrin-complexation on the chemical stability and degradation product formation of selected compounds were examined. The mechanism of degradation in aqueous solution was probed using 18O-labelled water and kinetic solvent isotope effect studies. The effect of stereochemistry was investigated using selected pairs of stereoisomers. The degradation of the ozonides in aqueous solution followed apparent first-order kinetics, with no effect of ionic strength and no indication of any direct involvement of water in the degradation mechanism. All major degradation products were identified and mass balance was confirmed. Stereochemistry had a significant effect on degradation rate; trans isomers degrading approximately four-fold faster than the corresponding cis isomers. The degradation rates were essentially independent of pH above pH 2; however, an additional specific acid catalysed pathway was dominant below pH 2. Solvent dielectric constant had a significant effect on the degradation rate. It is proposed that the degradation observed in aqueous solution occurred through a concerted heterolytic scission of the central ozonide ring, with chemical substituents on the cyclohexyl ring having only a minor influence on degradation rate. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95:737–747, 2006
Bartın Orman Fakültesi Dergisi
Mavi-Yeşil Altyapının Yeri ve Önemi: Erzurum Kenti Örneği2019 •
2019 •
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Pelatihan Penggunaan Alat Peraga Matematika bagi Guru SD GMIT Koro’oto, Kupang, Nusa Tenggara Timur2021 •
Diabetic Medicine
INPPL1is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy2012 •
Combinatorial Chemistry & High Throughput Screening
DNA and RNA Aptamers: From Tools for Basic Research Towards Therapeutic Applications2006 •
Asia-Pacific - Annual Research Journal of Far East & South East Asia
Cultural Diplomacy: The Case Study of Pakistan-Japan Cultural RelationsSustainable Energy & Fuels
Waste to wealth: spent catalyst as an efficient and stable bifunctional oxygen electrocatalyst for zinc–air batteries2021 •
International Journal o f Financial Studies
Uncovering the Effect of News Signals on Daily Stock Market Performance: An Econometric Analysis2023 •
Earthquake Spectra
Assessing post-disaster recovery using sentiment analysis: The case of L’Aquila, Italy2021 •
Journal of Internal Medicine
Anti-ApoA-I IgG antibodies are not associated with carotid artery disease progression and first-time cardiovascular events in middle-aged individuals2018 •
arXiv (Cornell University)
Carleman Estimates and null controllability of coupled degenerate systems2011 •
Apuntes universitarios
Investigación de los efectos de las actividades STEM en la actitud STEM en estudiantes superdotados2022 •
Proceedings of the Proceeding of the First International Graduate Conference (IGC) On Innovation, Creativity, Digital, & Technopreneurship for Sustainable Development in Conjunction with The 6th Roundtable for Indonesian Entrepreneurship Educators 2018 Universitas Syiah Kuala October, 3-5, 2018 B...
Accumulation of Pb and Zn in mollusk bivalves, Geloina erosa and its growth patterns in mangrove ecosystem of Reuleung, Aceh Besar District, Indonesia2019 •
Indonesian Contemporary Nursing Journal (ICON Journal)
Related Factors of Response Time in Handling Head Injury in Emergency Unit of PROF.DR.H.M.ANWAR Makkatutu Bantaeng General Hospital2018 •
IFIP Advances in Information and Communication Technology
Reinforcement Learning Using Monte Carlo Policy Estimation for Disaster Mitigation2014 •