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Currently the indiscriminate use of commercial antimicrobial agents has resulted in multiple drug resistance in human pathogenic microorganisms. To overcome the escalating problems associated with infectious diseases and drug resistance discovery of new antimicrobials is vital. Increased incidence of resistant in bacteria together with lack and high cost of new generation drugs has increased infection related morbidity and mortality particularly in developing countries. The present study was aimed to evaluate the in vitro antibacterial activity of Elytraria acaulis herb against the clinical pathogens. The Elytraria acaulis plant was collected; dried, powdered and serially extracted using the organic solvents in the Soxhlet apparatus and the antimicrobial activity was analyzed by Disc diffusion method and the Minimal Inhibitory Concentration (MIC) was analysed by Broth dilution technique against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. The methanolic extracts of Elytraria acaulis showed maximum antibacterial activity against all the tested pathogens and the MIC was ranged between 40 µg/ml to 5 µg/ml. The results obtained justified the antibacterial potential of the Elytraria acaulis against the clinically important pathogens. The bioactive compounds in the extracts will be helpful in herbal antimicrobial formulations.
Elytraria acaulis, a stem less perennial herb of Acantheceae family has many medicinal and therapeutic properties. Anti oxidative activity of the aerial parts of this Elytraria acaulis were assessed in the present study. The aerial parts of the plant (Stem & Leaves) were extracted in different organic solvents such as n-Hexane, Ethanol, Methanol, Ethyl Acetate and Chloroform. Initially, Total Phenolic & Total Flavonoids content in different solvent plant extracts were estimated. The free radical scavenging and antioxidant activity of the Elytraria acaulis aerial extracts in different organic solvents were also assayed by DPPH assay, FRAP assay. The aerial extracts of Elytraria acaulis have shown significant anti oxidant activity. Hence, further studies on this plant will enable elucidation of its therapeutic properties and medicinal applications.
International Journal of Pharmaceutical Investigation
Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line2021 •
Medicinal herbs have a long history in improving human health and curing various diseases. A wide interest has been made for researchers using herbal material in identification of the active components and verification of their efficiency. Many researches are working seriously to find out substitutes for antibiotics as they cause side effects on the functioning of different parts of the body, organs and systems over the last twenty years. The phytochemical analysis of the medicinal plants extracts showed that the presence of flavonoids, alkaloids, tannins, steroid and amino acid. Uses of phytochemical compound against pathogenesis. The investigation of plant extracts effective against staphylococcus aureus and Bacillus sp. The higher concentration (200 mg/disc) of methanol extract of Avicennia germinans showed significant antibacterial activity against six bacterial cultures from (10mm-32mm). In this present study it was interestingly recorded that the zones of inhibition of methonolic extract of Avicennia germinans were greater than the standard antibiotics which were used in the present research work.
International Journal of Life Sciences and Biotechnology
Antibacterial Activity of Ethanol Leaf Extract of Sida acuta Against Some Clinical Bacterial IsolatesPersistent evolution of multidrug resistance bacteria due to inappropriate use of conventional antibiotics is undermining treatment intervention for infectious diseases, thus constituting substantial proportion of the global public health problem. This, necessitated the search and development of new drugs particularly from plant origin that are effective against such superbugs. Therefore, the present study was designed to determine the phytochemical constituents in Sida acuta and their antibacterial effects on pathogenic bacterial species of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis. The phytochemical components of the extract were identified using standard methods. Furthermore, the antibacterial activity of the leaf extract against the bacterial pathogens were assessed using agar well diffusion and broth dilution method, at varying concentrations of the extract (37.50, 75, 150 and 300 mg/ml), and using Commercially obtained ciprofloxacin ...
2021 •
2020 •
Herbal medicine refers to the use of any plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Along with other dosage forms, herbal drugs are also formulated in the form of ointment. An ointment is a viscous semisolid preparation used topically on a variety of body surfaces. The objective of the study was to evaluate the Pharmacognostical, Phytochemical and evaluation of the antimicrobial herbal ointment from the different extracts of dried leaves of selected medicinal plants like Aerva Lanata, Bauhinia variegata, Acmella uliginosa. The anti-Microbial properties of extracts were evaluated by Agar well diffusion method using gram positive bacteria like Staphylococus aureus, Bacillus subtilius, gram negative bacteria like Escherichia coli, Klebseilia pneumonia. Amongst the test extracts, the results suggested that, Methonolic extracts showed significant anti-Microbial activity compared with standard drug. Plants show high efficiency of antimicrobial acti...
Journal of Experimental Pharmacology
Evaluation of the Antimicrobial Activity of Leaf Extracts of Acokanthera schimperi against Various Disease-Causing Bacteria2021 •
Background In traditional medicine of Ethiopia, Acokanthera schimperi is the one used to treat different infectious diseases. Hence, this study was conducted with the main aim of determining active compounds in the leaves of A. schimperi. Methods The antimicrobial activities of using disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and acute oral toxicity of the fraction. Results The average bacterial zone of inhibition of the dichloromethane (DCM), chloroform (TCM), petroleum ether (PE) and ethyl acetate (EA) fractions ranged from 7.67 mm to 18.12 mm. The average values of MIC of the DCM, TCM, PE and EA fractions ranged from 4.17 mg/mL to 33.34 mg/mL. The most susceptible bacterium at 200 mg/mL was S. typhi, (18.12mm), while the less susceptible bacterium was C. freundii (14.33mm). Conclusion The solvent fractions demonstrated significant antibacterial activities with varying spectrum and safe up to 2000mg/kg.
2019 •
This study sought to investigate the antimicrobial activity of sixBackground: plants used in traditional medicine in Africa. The antimicrobial activity of the six medicinal plant extracts (aqueousMethods: and ethanol) were evaluated against (ATCC 21784), Proteus mirabilis (ATCC27856) were using thePseudomonas aeruginosa Aspergillus fumigatus agar-well diffusion protocol. The activities of these extracts were compared with the positive controls chloramphenicol and griseofulvin. Similarly, the phytochemicals from the extracts were qualitatively assayed and their percentage yield calculated by standard methods. The bacterial organisms used, and , wereResults: P. mirabilis P. aeruginosa slightly-to-highly susceptible to aqueous and ethanolic extracts from the various test plants, while was insensitive to the treatments. The ethanolic A. fumigatus extracts of the sampled plants showed superior inhibitory performance on the target bacteria to the aqueous extracts. Aqueous and eth...
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