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Plant Neoflavonoids: Chemical Structures and Biological Functions

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Plant-derived Bioactives

Abstract

Neoflavonoids (NFs) constitute a remarkable group of naturally occurring flavonoids with C6-C3-C6 (4-phenylcoumarin) carbon skeleton. NFs are not often found in food and edible plants, but widely distributed in different plant families, including Fabaceae, Clusiaceae, Leguminosae, Rubiaceae, Passifloraceae, Thelypteridaceae, and Polypodiaceae. They are commonly being identified in various plants, belonging to Dalbergia genus. Because of dalbergin and other NFs, Dalbergia species are having medicinal importance, and more than 60 NFs are being isolated and identified so far from this genus. Depending on the pattern of substitution and sources, they are categorized into four groups, namely 4-arylcoumarins (neoflavones), 4-arylchromanes, dalbergiones, and dalbergiquinols. These compounds have been found to display several health beneficial effects. They have wide-ranging therapeutic properties, such as anti-osteoporosis, anti-inflammatory, antimicrobial, antiplasmodial, anti-androgen, anti-allergic, antioxidant, antifungal, antidiabetic, and anticancer activities. Additionally, NFs of various medicinally valued plants are being employed as herbal formulations in the traditional systems of medicine like Ayurveda, Unani, Chinese, etc., around the world. The aim of this chapter is to discuss different structures and biological functions of NFs isolated from different plant species with a particular focus on the recent therapeutic approaches.

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Authors and Affiliations

  1. Department of Chemistry, Maharishi Arvind University, Jaipur, Rajasthan, India

    Padam Kumar

  2. Department of Biotechnology, Era’s Lucknow Medical College & Hospital, Lucknow, Uttar Pradesh, India

    Tanveer Ahamad & Mohammad Faheem Khan

  3. Department of Applied Sciences and Humanities, Rajkiya Engineering College, Ambedkar Nagar, Uttar Pradesh, India

    Devendra Pratap Mishra

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  2. Tanveer Ahamad
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  1. Department of Biotechnology, East West First Grade College, Bengaluru, Karnataka, India

    Mallappa Kumara Swamy

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Kumar, P., Ahamad, T., Mishra, D.P., Khan, M.F. (2020). Plant Neoflavonoids: Chemical Structures and Biological Functions. In: Swamy, M. (eds) Plant-derived Bioactives. Springer, Singapore. https://doi.org/10.1007/978-981-15-2361-8_3

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