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2010, Pakistan Journal of Biological Sciences
Oriental Pharmacy and Experimental Medicine
In vitro xanthine oxidase inhibitory and antioxidant activities of aerial parts of Flacourtia sepiaria Roxb2013 •
Pharmacognosy research
Evaluation of antioxidant and xanthine oxidase inhibitory activity of different solvent extracts of leaves of Citrullus colocynthis2014 •
Citrullus colocynthis is a folk medicinal plan of United Arab Emirates. Several studies on this plant reported and focused on the biological and toxicological profile of fruits pulp. The present study focused on the antioxidant potency of leaf extract of this plant. To evaluate the antioxidant and xanthine oxidase (XO) inhibitory activities of C. colocynthis by chemical method. Four different solvent extracts (methanol-CCM, methanol: water (1:1)-CCMW, chloroform-CCC and hexane-CCH) of leaves of C. colocynthis were investigated for their free radical scavenging activity using DPPH radical as a substrate, lipid peroxidation (LPO) inhibitory activity using a model system consisting of β-carotene-linoleic acid, superoxide radical scavenging activity (enzymatically/nonenzymatically) and XO inhibitory activity. A dose response curve was plotted for determining SC50 and IC50 values for expressing the results of free radical scavenging activity and XO inhibitory activities respectively. The...
2016 •
Indonesian Journal of Chemistry
IN VITRO INHIBITION OF CELERY (Apium graveolens L.) EXTRACT ON THE ACTIVITY OF XANTHINE OXIDASE AND DETERMINATION OF ITS ACTIVE COMPOUND2012 •
The objective of this study was to determine the inhibition effect of celery extracts toward xanthine oxidase by in vitro method, and its active compounds. Roots and herb of celery were extracted using water and ethanol solvents. Results indicated that the herbal ethanol extract had the highest inhibition effect (91.40%) at 1400 ppm. The components contained in the herbal ethanol extract were then separated by column chromatography using the best eluent (chloroform : ethyl acetate at 7:3). All of the fractions had inhibition effect greater than 50%. The fraction number 4 was the one with the highest inhibition effect followed by fraction 5 with inhibition percentage of both fractions at 200 ppm were 88.62 and 85.44%, respectively. The analysis of the ultraviolet spectrum of fraction 4 showed the presence of π-π* transition which was resulted by the aromatic C=C, -OH, and C-O chromophores, and also showing the n-σ* transition which was given by -C=O chromophore. The infrared spectrum...
Journal of Pharmacy & Pharmacognosy Research
Metabolite profiling, in vitro antioxidant and xanthine oxidase inhibitory properties of six Sumatran sidaguri (Sida L.)Context: The Sida genus, part of the Malvaceae family, is commonly used in traditional medicine due to its many beneficial properties, such as antigout, anti-rheumatic, anti-inflammatory, antitumor, and hepatoprotective effects. Various species of Sida are found in Indonesia, particularly on the island of Sumatra, and may hold potential for future drug development. Aims: To assess and compare the methanol leaf extracts of three Sida species (S. acuta, S. rhombifolia, and S. cordifolia) from West Sumatra and South Sumatra, Indonesia, for their chemical content in metabolite profiling, in vitro antioxidant capacity, and xanthine oxidase inhibitory activity. Methods: The LC-MS/MS method was used to determine metabolite profiling, while spectrophotometry was used to assess total phenolic content, flavonoid content, antioxidant capacity, and xanthine oxidase inhibitor activity. Results: The results showed that S. rhombifolia (WS) had the highest total phenolic (64.872 ± 1.525 mg GAE/g) and flavonoid contents (13.890 ± 0.816 mg QE/g), S. acuta (SS) exhibited the highest antioxidant activity (IC50 147.295 ± 3.364 µg/mL), and S. cordifolia (WS) showed the highest xanthine oxidase inhibitor activity (IC50 110.087 ± 15.637 µg/mL). Conclusions: These findings suggest that S. acuta, S. rhombifolia, and S. cordifolia may be potential sources of polyphenols and antioxidants and could also serve as promising natural plant sources for developing antigout remedies.
Jordan Journal of Pharmaceutical Sciences
In Vitro Xanthine Oxidase Inhibition by Selected Jordanian Medicinal Plants2011 •
In the present study, 18 Jordanian medicinal plants were evaluated for their Xanthine Oxidase (XO) inhibitory potential. Their aqueous extracts, prepared from used parts, were tested in vitro, at 200 µg/mL concentration, for their inhibition potencies expressed as % inhibition of XO activity. Five of the tested plants were found most active (% inhibition more than 35%) and their inhibition profiles (dose-dependent) were further evaluated by estimating the IC50 values of their corresponding extracts. These plants were Hyoscyamus reticulatus L. (IC50 = 12.8 µg/mL), Achillea fragrantissima (Forssk.) Sch. Bip. (197.6 µg/mL), Pimpinella anisum L., (300.4 µg/mL), Origanum syriacum L. (317.0 µg/mL), and Origanum vulgare L. (403.9 µg/mL). Moreover, five more plants showed XO inhibitory activity in the range of 14-30%. Namely: Daphne linearifolia L. (29.5% inhibition), Hibiscus sabdariffa L. (19.4%), Aristolochia maurorum L. (15.6%), Citrullus colocynthis (L.) Schr. (14.4%), and Laurus nobil...
Human. Sport. Medicine
Possibilities of Regulating Antioxidant Activity of Medicinal Plant Extracts2017 •
Pharmaceutical Biology
Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus2010 •
Journal of Medicinal …
Kinetic Study on the Inhibition of Xanthine Oxidase by Extracts from Two Selected Algerian Plants Traditionally Used for the Treatment of Inflammatory Diseases2010 •
2011 •
In the present investigation an attempt was made to find a new herbal derived material with potential Xanthine oxidase inhibitory and free radical scavenging activities. We have screened the Ethanolic extracts of 10 medicinal plants belonging 8 families, regardless of their claimed ethanopharmacological and /or food uses for their XO inhibitory activities using an optimized protocol. The Super oxide, Nitric oxide, hydrogen peroxide radical scavenging activity and Total antioxidant activity of these extracts were investigated employing various established in vitro systems. Total phenolic and flavanoid content were also determined. The Xanthine oxidase enzyme inhibitory and the antioxidant activity of Ethanolic plant extract were found to be in the following order. Piper nigrum > Brassica juncea > Cuminum cyminum > Cinnamomum zeylanicum > Coriandrum sativum > Cinnamomum tamala > Nigella sativa > Elettaria cardamomum > Syzygium aromaticum > Prunus amygdalus. ...
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Patrimônio Cultural de João Pinheiro
CULTURAS E SOCIEDADE religiosidade, identidades e territórios2022 •
Cuadernos de Administración
La gerencia venezolana. Una perspectiva desde la complejidadIEEE Transactions on Automatic Control
Solution of finite-time optimal control problems with mixed end constraints in the s-domain1979 •
2020 •
Toxicological Sciences
Comparing the Predictivity of Human Placental Gene, microRNA, and CpG Methylation Signatures in Relation to Perinatal Outcomes2021 •
2013 •
Eastern-European Journal of Enterprise Technologies
A robomech class parallel manipulator with three degrees of freedom2020 •
2018 •
Innovation in Aging
Exploring Aging Masculinities From Different Disciplines and Perspectives2020 •
JIKOBA (Jurnal Ilmu Komunikasi Balayudha)
ANALISIS PESAN DAN DAMPAK ANIME BERGENRE AKSI PADA MAHASISWA UNIVERSITAS ISLAM NEGERI AR-RANIRY BANDA ACEH2023 •
International Journal of Immunopathology and Pharmacology
Plasma energy substrates at two stages of Alzheimer’s disease in humans2018 •
2022 •
2018 •
2011 •
Journal of Threatened Taxa
Extended distribution of Dipcadi concanense (Dalzell) Baker - a highly threatened plant taxon of the family Asparagaceae2016 •