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2004 •
ThepresentreviewdescribesresearchonnovelnaturalisoquinolinealkaloidsandtheirN-oxidesisolatedfromdifferentplantspecies.Morethan200biologicalactivecompoundshaveshownconfirmedantimicro-bial,antibacterial,antitumor,andotheractivities.Thestructures,origins,andreportedbiologicalactivitiesofaselectionofisoquinolineN-oxidesalkaloidsarereviewed.WiththecomputerprogramPASSsomead-ditionalSAR(structure–activityrelationship)activitiesarealsopredicted,whichpointtowardnewpossibleapplicationsofthesecompounds.ThisreviewemphasizestheroleofisoquinolineN-oxidesalkaloidsasanimportantsourceofleadsfordrugdiscovery.
Plants produce many secondary metabolites, which reveal biological activity [...]
Journal of ethnopharmacology
Huperzine A from Huperzia species--an ethnopharmacolgical review2007 •
Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.
Phytochemical Analysis
LC-MS/MS Quantitative Determination of Tetrapterys mucronata Alkaloids, a Plant Occasionally used in Ayahuasca Preparation2015 •
2013 •
Journal of analytical methods in chemistry
Simultaneous Quantification of Limonin, Two Indolequinazoline Alkaloids, and Four Quinolone Alkaloids in Evodia rutaecarpa (Juss.) Benth by HPLC-DAD Method2013 •
A simple and efficient HPLC-DAD (225 nm) method was developed and validated for the simultaneous determination of limonin and six key alkaloids (evodiamine, rutaecarpine, 1-methyl-2-undecyl-4(1H)-quinolone, evocarpine, 1-methy-2-[(6Z,9Z)]-6,9-pentadecadienyl-4-(1H)-quinolone, and dihydroevocarpine) in Evodia rutaecarpa (Juss.) Benth, which has been widely used as one of the Traditional Chinese Medicines. The chromatographic separation was carried out on a Hypersil BDS C18 column, and gradient elution was employed with a mobile phase containing acetonitrile and water. Contents of the analytes in 18 batches of samples were analyzed by ultrasonic extraction with ethanol and water mixture (80 : 20, v/v) followed by HPLC analysis. Separation of the seven analytes was achieved within 60 min with good linearity (r > 0.999). The RSD of both the intraday and interday precision was below 1.85%. The accuracy at different concentrations was within the range of 97.91 to 100.49%. Hierarchical ...
Pan African Medical Journal
Les grosses bourses aiguës au centre hospitalier de Louga, Sénégal: aspects épidémiologiques, étiologiques et thérapeutiques2016 •
Journal of Anatolian Environmental and Animal Sciences
Identification and Treatment of Hexamitiasis Observed in Rainbow Trout (Oncorhynchus mykiss) Fry1987 •
2017 •
2019 •
Issue briefs
Synopsis of Socioeconomic considerations in biosafety descisionmaking: Methods and implementation2013 •
Journal of Applied Sciences
Enhancement of Education in Farm and Food Industry With Adoption of Computer-Based Information Systems2008 •
Advanced Materials Interfaces
Oxygen Vacancy Dependence of Magnetic Behavior in the LaAlO 3 /SrTiO 3 Heterostructures2016 •
Environmental Geochemistry and Health
Assessing the geochemical and environmental baseline of heavy metals in soils around hydrothermal hematite–barite–galena veins in Baghin area, Kerman, Iran2020 •
2016 •
International Journal of Education Research and Development
Improving Teacher's Ability to Understand Gender Equality in the Mathematics Learning through Academic Supervision in Vocational High SchoolFrontiers in Bioengineering and Biotechnology
Integrated Continuous Bioprocess Development for ACE-Inhibitory Peptide Production by Lactobacillus helveticus Strains in Membrane Bioreactor2020 •
2016 •
Applied Environmental Research
Mineral Resources Potential of Vietnam and Current State of Mining Activity2014 •
Advances in higher education and professional development book series
Models for Improving and Optimizing Online and Blended Learning in Higher Education2015 •
Turkish Journal of Anesthesia and Reanimation
Stop Being So Sensitive: An Exceptionally Rare Report of Ustekinumab-Induced Sub-acute Hypersensitivity Pneumonitis2017 •
European Radiology Experimental
Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience2023 •