Skip to main content
SpringerLink
Log in

Fomitopsis betulina (Bull.) B.K. Cui, M.L. Han & Y.C. Dai; Fomitopsis pinicola (Sw.) P. Karst. - FOMITOPSIDACEAE

  • Chapter
  • First Online:
Ethnobiology of Uzbekistan

Part of the book series: Ethnobiology ((EBL))

  • 27 Accesses

Abstract

Fomitopsis betulina (Bull.) B.K. Cui, M.L. Han & Y.C. Dai; Fomitopsis pinicola (Sw.) P. Karst. - FOMITOPSIDACEAE

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alresly Z (2019) Chemical and pharmacological investigations of Fomitopsis betulina (formerly: Piptoporus betulinus) and Calvatia gigantea. Mathematisch-Naturwissenschaftliche Fakultät der Universität GreifswaId, pp 1–241

    Google Scholar 

  • Alresly Z, Lindequist U, Lalk M, Porzel A, Arnold N, AWessjohann, L. (2016) Bioactive triterpenes from the fungus Piptoporus betulinus. Rec Nat Prod 10(1):103

    CAS  Google Scholar 

  • Bernicchia A, Gorjón SP (2020) Polypores of the Mediterranean Region. Segrate, Romar, 903 p

    Google Scholar 

  • Bishop KS (2020) Characterisation of extracts and anti-cancer activities of Fomitopsis pinicola. Nutrients 12(3):609–619

    CAS  PubMed  PubMed Central  Google Scholar 

  • Borenfreund E, Puerner JA (1985) Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 24(2–3):119–124

    CAS  PubMed  Google Scholar 

  • Bryce TA, Campbell IM, McCorkindale NJ (1967) Metabolites of the polyporaceae-I. Novel conjugates of polyporenic acid A from Piptoporus betulinus. Tetrahedron 23:3427–3434

    CAS  Google Scholar 

  • Cha WS, Ding JL, Shin HJ, Kim JS, Kim YS, Choi D, Lee HD, Kang HB, Lee CW (2009) Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats. Korean J Chem Eng 26(6):1696–1699

    CAS  Google Scholar 

  • Chandramu C, Manohar RD, Krupadanam DG, Dashavantha RV (2003) Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother Res 17(2):129–134

    CAS  PubMed  Google Scholar 

  • Cheng S, Eliaz I, Lin J, Thyagarajan-Sahu A, Sliva D (2013) Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. Int J Oncol 42(6):1869–1874

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cross LC, Eliot CG, Heilborn IM, Jones ERH (1940) Constituents of the higher fungi. Part I. The triterpene acids of Polyporus betulinus Fr. J Chem Soc:632–636

    Google Scholar 

  • Eiznhamer DA, Xu ZQ (2004) Betulinic acid: a promising anticancer candidate. Drugs 7:359–373

    CAS  Google Scholar 

  • FujiMoto H, Nakayama M, Nakayama Y, Yamazaki M (1994) Isolation and characterization of immunosuppressive components of three mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina. Chem Pharm Bull 42(3):694–697

    CAS  Google Scholar 

  • Fulda S, Debatin KM (2000) Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med Pediatr Oncol 35(6):616–618

    CAS  PubMed  Google Scholar 

  • Gafforov Y, Ordynets A, Langer E, Yarasheva M, de Mello Gugliotta A, Schigel D, Pecoraro L, Zhou Y, Cai L, Zhou LW (2020) Species Diversity with comprehensive annotations of wood-inhabiting poroid and corticioid fungi in Uzbekistan. Front Microbiol 11:598321. https://doi.org/10.3389/fmicb.2020.598321

    Article  PubMed  PubMed Central  Google Scholar 

  • Gao JM, Wang M, Liu LP, Wei GH, Zhang AL, Draghici C, Konishi Y (2007) Ergosterol peroxides as phospholipase A2 inhibitors from the fungus Lactarius hatsudake. Phytomedicine 14(12):821–824

    CAS  PubMed  Google Scholar 

  • Gilbertson RL, Ryvarden L (1987) North American polypores, vol 1. Oslo, Fungiflora, 433 p

    Google Scholar 

  • Grienke U, Zöll M, Peintner U, Rollinger JM (2014) European medicinal polypores- a modern view on traditional uses. J Ethnopharmacol 154:564–583

    PubMed  Google Scholar 

  • Guider M, Halsall TG, Hodges R, Jones ERH (1954) The chemistry of the triterpenes and related compounds. Part XXVI. The nature of polyporenic acid B. J Chem Soc (Resumed):3234–3238

    Google Scholar 

  • Hobbs C (2002) Medicinal mushrooms: an exploration of tradition, healing, & culture. Botanica Press

    Google Scholar 

  • https://ultimate-mushroom.com/edible/88-fomitopsis-betulina.html

  • Hybelbauerová S, Sejbal J, Dračínský M, Hahnová A, Koutek B (2008) Chemical constituents of Stereum subtomentosum and two other birch-associated Basidiomycetes: an interspecies comparative study. Chem Biodivers 5(5):743–750

    PubMed  Google Scholar 

  • Jong SC, Donovick R (1989) Antitumor and antiviral substances from fungi. Adv Appl Microbiol 34:183–262

    CAS  PubMed  Google Scholar 

  • Kamo T, Asanoma M, Shibata H, Hirota M (2003) Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus. J Nat Prod 66(8):1104–1106

    CAS  PubMed  Google Scholar 

  • Kawagishi H, Hamajima K, Inoue Y (2002) Novel hydroquinone as a matrix metallo-proteinase inhibitor from the mushroom, Piptoporus betulinus. Biosci Biotechnol Biochem 66(12):2748–2750

    CAS  PubMed  Google Scholar 

  • Keller AC, Maillard MP, Hostettmann K (1996) Antimicrobial steroids from the fungus Fomitopsis pinicola. Phytochemistry 41(4):1041–1046

    CAS  PubMed  Google Scholar 

  • Khalilov Q, Li L, Liu Y, Tohtahon Z, Chen X, Aisa HA, Yuan T (2019) Piptolinic acids F-J, five new lanostane-type triterpenoids from Piptoporus betulinus. Nat Prod Res 33(21):3044–3051

    CAS  PubMed  Google Scholar 

  • Kindler S, Schuster M, Seebauer C, Rutkowski R, Hauschild A, Podmelle F, Metelmann C, Metelmann B, Müller-Debus C, Metelmann HR, Metelmann I (2016) Triterpenes for well-balanced scar formation in superficial wounds. Molecules 21(9):1129. https://doi.org/10.3390/molecules21091129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krasutsky PA (2006) Birch bark research and development. Nat Prod Rep 23(6):919–942

    CAS  PubMed  Google Scholar 

  • Kuo PC, Tai SH, Hung CC, Hwang TL, Kuo LM, Lam SH, Cheng KC, Kuo DH, Hung HY, Wu TS (2021) Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola. Bioorg Chem 108:104562

    CAS  PubMed  Google Scholar 

  • Kuo YC, Weng SC, Chou CJ, Chang TT, Tsai WJ (2003) Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. Br J Pharmacol 140:895–906

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lee SI, Kim JS, Oh SH, Park KY, Lee HG, Kim SD (2008) Antihyperglycemic effect of Fomitopsis pinicola extracts in streptozotocin-induced diabetic rats. J Med Food 11(3):518–524

    CAS  PubMed  Google Scholar 

  • Lemieszek MK, Langner E, Kaczor J, Kandefer-Szerszen M, Sanecka B, Mazurkiewicz W, Rzeski W (2009) Anticancer effect of fraction isolated from medicinal birch polypore mushroom, Piptoporus betulinus (Bull.: Fr.) P. Karst. (Aphyllophoromycetideae): in vitro studies. Int J Med Mushrooms 11(4):351–364

    CAS  Google Scholar 

  • Li G, Xu ML, Lee CS, Woo MH, Chang HW, Son JK (2004) Cytotoxicity and dna topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocos. Arch Pharm Res 27(8):829–833

    CAS  PubMed  Google Scholar 

  • Ling H, Zhou L, Jia X, Gapter LA, Agarwal R, Ng KY (2009) Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. Mol Carcinog 48(6):498–507

    CAS  PubMed  Google Scholar 

  • Liu W, Ho J, Cheung F, Liu B (2004) Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. Eur J Pharmacol 498:71–78

    CAS  PubMed  Google Scholar 

  • Liu Y, Liu W, Li M, Yuan T (2022) Lanostane triterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activities. Phytochemistry 193:112985

    CAS  PubMed  Google Scholar 

  • Marcus S (1952) Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. Biochem J 50(4):516–517

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miles PG, Chang ST (2004) Mushrooms: cultivation, nutritional value, medicinal effect, and environmental impact. CRC Press

    Google Scholar 

  • Nam KS, Jo YS, Kim YH, Hyun JW, Kim HW (2001) Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes. Life Sci 69(2):229–237

    CAS  PubMed  Google Scholar 

  • Papp N, Rudolf K, Bencsik T, Czégényi D (2017) Ethnomycological use of Fomes fomentarius (L.) Fr. and Piptoporus betulinus (Bull.) P. Karst. in Transylvania, Romania. Genet Resour Crop Evol 64:101–111. https://doi.org/10.1007/s10722-015-0335-2

    Article  Google Scholar 

  • Peintner U, Pöder R, Pümpel T (1998) The iceman’s fungi. Mycol Res 102:1153–1162

    Google Scholar 

  • Peng XR, Su HG, Liu JH, Huang YJ, Yang XZ, Li ZR, Zhou L, Qiu MH (2019) C30 and C31 triterpenoids and triterpene sugar esters with cytotoxic activities from edible mushroom Fomitopsis pinicola (Sw. ex Fr.) Krast. J Agric Food Chem 67(37):10330–10341

    CAS  PubMed  Google Scholar 

  • Rösecke J, König WA (1999) Steroids from the fungus Fomitopsis pinicola. Phytochemistry 52(8):1621–1627

    Google Scholar 

  • Rutalek R (2002) Ethnomykologie–Eine Übersicht. Österreichische Zeitschrift für Pilzkunde 11:79–94

    Google Scholar 

  • Ryvarden L, Gilbertson RL (1993) European polypores. 1. Abortiporus—Lindtneria; Fungi Flora: Oslo, 387

    Google Scholar 

  • Semerdžieva M, Veselský J (1986) Léčivé houby dřive a nyni. Academia Praha, Praha

    Google Scholar 

  • Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N (2004) Immunostimulating and anti-tumor action of extracts of several mushrooms. J Biotechnol 13:77–83. https://doi.org/10.1016/j.jbiotec.2004.04.034

    Article  CAS  Google Scholar 

  • Schlegel B, Luhmann U, Haertl A, Graefe U (2000) Piptamine, a new antibiotic produced by Piptoporus betulinus Lu 9-1. J Antibiot 53(9):973–974

    CAS  Google Scholar 

  • Sofrenić I, Anđelković B, Todorović N, Stanojković T, Vujisić L, Novaković M, Milosavljević S, Tešević V (2021) Cytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulina. Phytochemistry 181:112580

    PubMed  Google Scholar 

  • Stamets P (1993) Growing gourmet and medicinal mushrooms. Ten Speed Press

    Google Scholar 

  • Sukowska-Ziaja K, Muszynska B, Motyl P, Pasko P, Ekiert H (2012) Phenolic compounds and antioxidant activity in some species of polyporoid mushrooms from Poland. Int J Med Mushrooms 14(4):385–393

    Google Scholar 

  • Tai SH, Kuo PC, Hung CC, Lin YH, Hwang TL, Lam SH, Kuo DH, Wu JB, Hung HY, Wu TS (2019) Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity. RSC Adv 9(59):34184–34195

    CAS  PubMed  PubMed Central  Google Scholar 

  • Takei T, Yoshida M, Ohnishi-Kameyama M, Kobori M (2005) Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito. Biosci Biotechnol Biochem 69(1):212–215

    CAS  PubMed  Google Scholar 

  • Tohtahon Z, Xue J, Han J, Liu Y, Hua H, Yuan T (2017) Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus. Phytochemistry 143:98–103

    CAS  PubMed  Google Scholar 

  • Verekar SA, Gupta MK, Deshmukh SK (2021) Fomitopsis betulina: a rich source of diverse bioactive metabolites. In: Sridhar KR, Deshmukh SK (eds) Advances in “advances in macrofungi: pharmaceuticals and cosmeceuticals”. CRC Press, pp 22–66

    Google Scholar 

  • Wang Y, Cheng X, Wang P, Wang L, Fan J, Wang X, Liu Q (2014) Investigating migration inhibition and apoptotic effects of Fomitopsis pinicola chloroform extract on human colorectal cancer SW-480 cells. PLoS One 9(7):e101303

    PubMed  PubMed Central  Google Scholar 

  • Wangun HVK, Berg A, Hertel W, Nkengfack AE, Hertweck C (2004) Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus. J Antibiot 57(11):755–758

    CAS  Google Scholar 

  • Wasser SP (2010) Medicinal mushroom science: history, current status, future trends, and unsolved problems. Int J Med Mushrooms 12:1–16. https://doi.org/10.1615/IntJMedMushr.v12.i1.10

    Article  CAS  Google Scholar 

  • Weber LA, Puff C, Kalbitz J, Kietzmann M, Feige K, Bosse K, Rohn K, Cavalleri JV (2020) Concentration profiles and safety of topically applied betulinic acid and NVX-207 in eight healthy horses-A randomized, blinded, placebo-controlled, crossover pilot study. J Vet Pharmacol Ther 44(1):47–57. https://doi.org/10.1111/jvp.12903

    Article  CAS  PubMed  Google Scholar 

  • Ying J, Mao X, Ma Q, Zong Y, Wen H (1987) Icones of medical fungi from China. Wang, H. and Fan, S. Beijing, Science Press

    Google Scholar 

  • Yoshikawa K, Inoue M, Matsumoto Y, Sakakibara C, Miyataka H, Matsumoto H, Arihara S (2005) Lanostane Triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. J Nat Prod 68(1):69–73

    CAS  PubMed  Google Scholar 

  • Zhang J, Chen B, Liang J, Han J, Zhou L, Zhao R, Liu H, Dai H (2020) Lanostane Triterpenoids with PTP1B inhibitory and glucose-uptake stimulatory activities from mushroom Fomitopsis pinicola collected in North America. J Agric Food Chem 68(37):10036–10049

    CAS  PubMed  Google Scholar 

  • Zwolińska K (2004) Evaluation of anticancer activity of extracts from birch polypore Piptoporus betulinus (Bull. ex Fr.) P. Karst. Dissertation, Maria Curie-Skłodowska University, Lublin

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New Uzbekistan University, Tashkent, Uzbekistan

    Yusufjon Gafforov

  2. Mycology Laboratory, Institute of Botany, Academy of Sciences of Republic of Uzbekistan, Tashkent, Uzbekistan

    Yusufjon Gafforov

  3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P.R. China

    Yusufjon Gafforov

  4. R&D Division, Greenvention Biotech Pvt. Ltd., Pune, Maharashtra, India

    Sunil K. Deshmukh

  5. Parle Agro Pvt. Ltd., Corporate Head Office, Mumbai, India

    Shilpa A. Verekar

  6. Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Brno, Czech Republic

    Michal Tomšovský

  7. Tashkent International University of Education, Tashkent, Uzbekistan

    Manzura Yarasheva

  8. College of Landscape Architecture, Jiangsu Vocational College of Agriculture and Forestry, Zhenjiang, P.R. China

    Jia-Jia Chen

  9. Department of Ecology, University Kassel, Kassel, Germany

    Ewald Langer

  10. CEFE, CNRS, Univ Montpellier, EPHE, IRD, Laboratory of Botany, Phytochemistry and Mycology, Faculty of Pharmacy, Montpellier, France

    Sylvie Rapior

Authors
  1. Yusufjon Gafforov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sunil K. Deshmukh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shilpa A. Verekar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michal Tomšovský
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Manzura Yarasheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jia-Jia Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ewald Langer
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sylvie Rapior
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yusufjon Gafforov .

Editor information

Editors and Affiliations

  1. Tashkent Botanical Garden named after Academician F. N. Rusanov at Institute of Botany of Uzbek Academy of Sciences, Tashkent, Uzbekistan

    Olim K. Khojimatov

  2. New Uzbekistan University, Tashkent, Uzbekistan

    Yusufjon Gafforov

  3. Department of Ethnobotany, State Museum of Natural History, Karlsruhe, Germany

    Rainer W. Bussmann

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gafforov, Y. et al. (2023). Fomitopsis betulina (Bull.) B.K. Cui, M.L. Han & Y.C. Dai; Fomitopsis pinicola (Sw.) P. Karst. - FOMITOPSIDACEAE. In: Khojimatov, O.K., Gafforov, Y., Bussmann, R.W. (eds) Ethnobiology of Uzbekistan. Ethnobiology. Springer, Cham. https://doi.org/10.1007/978-3-031-23031-8_108

Download citation

Publish with us

Policies and ethics

Search

Navigation