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Valorization of coffee leaves as a potential agri-food resource: bio-active compounds, applications and future prospective

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Abstract

Main conclusion

This article intends to summarize all the up-to-date information on coffee leaves, rendering it to be used as a potential agri-food resource in the growing functional foods and pharma industries.

Abstract

Coffee leaves have been processed for herbal tea and ethno-medicine since centuries in the parts of the world where coffee is grown traditionally. Currently, interest in the valorisation of coffee leaves for its application in the food industry is proliferating and the research related to it is scanty and, therefore, worthwhile to congregate. The current review compromises the botanical description, chemical composition, bio-actives and ethnomedicinal properties of coffee leaves. It encompasses the existing pharmacological studies on coffee leaves including the anti-oxidant, anti-inflammatory and anti-obesity activities to pave path for future research. Furthermore, applications and patents associated with coffee leaves in different fields such as therapeutic agents, beverages, packaging material, tobacco substitute etc. have been summarized. The investigation reveals that, despite of many patents on coffee leaves only few products could reach the worldwide market; also in spite of coffee leaves having a rich ethno-medicinal use the study on its pharmacological activities are scarce which creates a huge scope to carry out in-vitro and in-vivo research on its various bio-activities. Future insights reflecting the supplementary research regarding the sensory attributes, changes in phytochemical composition, flavour development and product formulations which is vital are also discussed. In conclusion, this review addresses the breach and specifies the requirements to convert the existing knowledge into commercialized food products with functional properties. Thus, coffee leaves being a copious resource of bio-actives serve as a potential agri-food resource and a promising future in the emerging functional food and nutraceutical industry.

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References

  • Acidri R, Sawai Y, Sugimoto Y, Handa T, Sasagawa D, Masunaga T, Nishihara E (2020) Phytochemical profile and antioxidant capacity of coffee plant organs compared to green and roasted coffee beans. Antioxidants 9:93

    Article  CAS  Google Scholar 

  • Adams WW, Zarter CR, Ebbert V, Demmig-Adams B (2004) Photoprotective strategies of overwintering evergreens. Bioscience 54:41–49. https://doi.org/10.1641/0006-3568

    Article  Google Scholar 

  • Ashihara H, Crozier A (1999) Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea. J Agric Food Chem 47:3425–3431. https://doi.org/10.1021/jf981209n

    Article  CAS  PubMed  Google Scholar 

  • Ashihara H, Crozier A (2001) Caffeine: a well known but little mentioned compound in plant science. Trends Plant Sci 6:407–413. https://doi.org/10.1016/S1360-1385(01)02055-6

    Article  CAS  PubMed  Google Scholar 

  • Ashihara H, Monteiro AM, Gillies FM, Crozier A (1996) Biosynthesis of caffeine in leaves of coffee. Plant Physiol 111:747–753. https://doi.org/10.1104/pp.111.3.747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ashihara H, Ludwig IA, Katahira R, Yokota T, Fujimura T, Crozier A (2015) Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health. Phytochem Rev 14:765–798. https://doi.org/10.1007/s11101-014-9375-z

    Article  CAS  Google Scholar 

  • Bacon CM, Sundstrom WA, Gomez MEF, Mendez VE, Santos R, Goldoftas B, Dougherty I (2014) Explaining the ‘hungry farmer paradox’: smallholders and fair trade cooperatives navigate seasonality and change in Nicaragua’s corn and coffee markets. Glob Environ Change 25:133–149. https://doi.org/10.1016/j.gloenvcha.2014.02.005

    Article  Google Scholar 

  • Barrett B (1994) Medicinal plants of Nicaragua’s Atlantic Coast. Econ Bot 48:8. https://doi.org/10.1007/BF02901375

    Article  Google Scholar 

  • Berquist HM (2000) Organic fungicide. US Patent US-6616952-B1

  • Bertrand C, Noirot M, Doulbeau S, De Kochko A, Hamon S, Campa C (2003) Chlorogenic acid content swap during fruit maturation in Coffea pseudozanguebariae qualitative comparison with leaves. Plant Sci 165:1355–1361. https://doi.org/10.1016/j.plantsci.2003.07.002

    Article  CAS  Google Scholar 

  • Bridson DM, Verdcourt B (1988) Flora of tropical East Africa. Rubiaceae (Part 2). Rotterdam: Balkema, pp 415–747

  • Campa C, Mondolot L, Rakotondravao A, Bidel LPR, Gargadennec A, Couturon E, La Fisca P, Rakotomalala JJ, Jay-Allemand C, Davis AP (2012) A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses. Ann Bot 110:595–613. https://doi.org/10.1093/aob/mcs119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Campa C, Urban L, Mondolot L, Fabre D, Roques S, Lizzi Y, Aarrouf J, Doulbeau S, Breitler JC, Letrez C, Toniutti L, Bertrand B, La Fisca P, Bidel LPR, Etienne H (2017) Juvenile coffee leaves acclimated to low light are unable to cope with a moderate light increase. Front Plant Sci 8:1–16. https://doi.org/10.3389/fpls.2017.01126

    Article  Google Scholar 

  • Campa C, Petitvallet A (2017) Beneficial compounds from coffee leaves. In: Lashermes P (ed) Achieving sustainable cultivation of coffee, Burleigh Dodds Science Publishing Limited, Cambridge

  • Chaves ARM, Ten-Caten A, Pinheiro HA, Ribeiro A, Damatta FM (2008) Seasonal changes in photoprotective mechanisms of leaves from shaded and unshaded field-grown coffee (Coffea arabica L.) trees. Trees Struct Funct 22:351–361. https://doi.org/10.1007/s00468-007-0190-7

    Article  CAS  Google Scholar 

  • Chen XM, Ma Z, Kitts DD (2018) Effects of processing method and age of leaves on phytochemical profiles and bioactivity of coffee leaves. Food Chem 249:143–153. https://doi.org/10.1016/j.foodchem.2017.12.073

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Mu K, Kitts DD (2019) Characterization of phytochemical mixtures with inflammatory modulation potential from coffee leaves processed by green and black tea processing methods. Food Chem 271:248–258. https://doi.org/10.1016/j.foodchem.2018.07.097

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Ding J, Ji D, He S, Ma H (2020) Optimization of ultrasonic-assisted extraction conditions for bioactive components from coffee leaves using the Taguchi design and response surface methodology. J Food Sci 85:1742–1751. https://doi.org/10.1111/1750-3841.15111

    Article  CAS  PubMed  Google Scholar 

  • Chu YF, Chen Y, Black RM, Brown PH, Lyle BJ, Liu RH, Ou B (2011) Type 2 diabetes-related bioactivities of coffee: assessment of antioxidant activity, NF-κB inhibition, and stimulation of glucose uptake. Food Chem 124:914–920. https://doi.org/10.1016/j.foodchem.2010.07.019

    Article  CAS  Google Scholar 

  • Clifford MN, Williams T, Bridson D (1989) Chlorogenic acids and caffeine as possible taxonomic criteria in Coffea and Psillanthus. Phytochemistry 28:829–838

    Article  CAS  Google Scholar 

  • Daglia M, Papetti A, Gregotti C, Bertè F, Gazzani G (2000) In vitro antioxidant and ex vivo protective activities of green and roasted coffee. J Agric Food Chem 48:1449–1454. https://doi.org/10.1021/jf990510g

    Article  CAS  PubMed  Google Scholar 

  • de Almeida RF, Trevisan MTS, Thomaziello RA, Breuer A, Klika KD, Ulrich CM, Owen RW (2019) Nutraceutical compounds: Echinoids, flavonoids, xanthones and caffeine identified and quantitated in the leaves of Coffea arabica trees from three regions of Brazil. Food Res Int 115:493–503. https://doi.org/10.1016/j.foodres.2018.10.006

    Article  CAS  PubMed  Google Scholar 

  • Fibrianto K, Daryanto KA, Sholihah N, Wahibah LY, Hasyati N, Al-Baarri AN, Hariyadi DM (2020) Sensory profiling of Robusta and Liberica coffee leaves functional tea by modifying brewing temperature. IOP Conf Ser Earth Environ Sci 475:012028. https://doi.org/10.1088/1755-1315/475/1/012028

    Article  Google Scholar 

  • Fidele R (1990) Solution of plant extracts, its preparation and therapeutic composition containing it. France Patent FR-2661613-A1

  • Folmer B (2016) The craft and science of coffee. Academic Press, New York

    Google Scholar 

  • Fujimori N, Ashihara H (1994) Biosynthesis of theobromine and caffeine in developing leaves of Coffea arabica. Phytochemistry 36:1359–1361. https://doi.org/10.1016/S0031-9422(00)89724-1

    Article  CAS  Google Scholar 

  • Furukawa Y, Hizaki S, Kinugawa Y, Nii A, Yamauchi M, Yoshimura H (1991b) Coffee leaf tea and its preparation H. Japan Patent JP-H05168409-A

  • Furukawa Y, Hizaki S, Iguchi K, Nii A, Yamauchi M, Yoshimura H (1991a) Antibacterial agent and its production. Japan Patent JP-H05168447-A

  • Furukawa Y, Hizaki S, Nii H, Yamauchi M, Yoshimur H (1992b) Lactic acid proliferating agent and its production. Japan Patent JP-H06125771-A

  • Furukawa Y, Hizaki S, Nii A, Yamauchi M, Yoshimura H (1992a) Production of coffee leaf tea. JP-H0678676-A

  • Hirose Y, Yoshimura K, Yamamoto K (2011) Manufacturing method of coffee leaf tea raw material, and coffee leaf tea beverage using the same. Japan Patent JP-2013106536-A

  • Hizaki S, Yamauchi M (1992) Enteric-coated lactobacillus granule. Japan Patent JP-H06133735-A

  • Holloway PJ, Deas AHB, Kabaara AM (1972) Composition of cutin from coffee leaves. Phytochemistry 11:1443–1447. https://doi.org/10.1016/S0031-9422(00)90098-0

    Article  CAS  Google Scholar 

  • Huang S (2014) Burnt wolfberry leaf tea and preparation method thereof. China Patent CN-104431159-A

  • Inami O, Nakamura A, Otawa T, Yamamoto N (2002) Blood fluidity improving agent. Japan Patent JP-2004035478-A

  • Inoue M (1994) Coffee leaf tea and its preparation. Japan Patent JPH08173111-A

  • Ivamoto ST, Sakuray LM, Ferreira LP, Pereira LFP, Ivamoto ST, Sakuray LM, Kitzberger CSG, Scholz MBS, Pot D, Leroy T, Vieira LGE, Domingues DS, Pereira LFP (2017) Diterpenes biochemical profile and transcriptional analysis of cytochrome P450s genes in leaves, roots, flowers, and during Coffea arabica L. fruit development. Plant Physiol Biochem 111:340–347. https://doi.org/10.1016/j.plaphy.2016.12.004

    Article  CAS  PubMed  Google Scholar 

  • Iwai K, Nakabayashi Y (2000) Coffee leaf tea and method for producing the same. Japan Patent JP-2002191332-A

  • Júnior APD, Shimizu MM, Moura JCMS, Catharino RR, Ramos RA, Ribeiro RV, Mazzafera P (2012) Looking for the physiological role of anthocyanins in the leaves of Coffea arabica. Photochem Photobiol 88:928–937. https://doi.org/10.1111/j.1751-1097.2012.01125.x

    Article  CAS  Google Scholar 

  • K€olling-Speer I, Speer K (1997) Diterpenes in coffee leaves. In 17th international colloquium on the chemistry of coffee. Paris: ASIC

  • Kamiya H (2016) Manufacturing method of beverage raw material. Japan Patent JP-2017153463-A

  • Kim TH, Lim HJ, KimLee MSMS (2012) Dietary supplements for benign prostatic hyperplasia: an overview of systematic reviews. Maturitas 73:180–185. https://doi.org/10.1016/j.maturitas.2012.07.007

    Article  PubMed  Google Scholar 

  • Kim TH, Lee SS, Lee HH, Bae HK, Song JA, Kim JM (2015) Absorbent pad containing coffee leaves. Korean Patent KR-101754481-B1

  • Klingel T, Kremer JI, Gottstein V, Rajcic de Rezende T, Schwarz S, Lachenmeier DW (2020) A review of coffee by-products including leaf, flower, cherry, husk, silver skin, and spent grounds as novel foods within the European Union. Foods 9:665

    Article  CAS  Google Scholar 

  • Ky CL, Louarn J, Dussert S, Guyot B, Hamon S, Noirot M (2001) Caffeine, trigonelline, chlorogenic acids and sucrose diversity in wild Coffea arabica L. and C. canephora P. accessions. Food Chem 75:223–230. https://doi.org/10.1016/S0308-8146(01)00204-7

    Article  CAS  Google Scholar 

  • Lamorde M, Tabuti JR, Obua C, Kukunda-Byobona C, Lanyero H, Byakika-Kibwika P et al (2010) Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda. J Ethnopharmacol 130:43–53

    Article  Google Scholar 

  • Lelo A, Miners JO, Robson R, Birkett DJ (1986) Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines. Clin Pharmacol Ther 39:54–59. https://doi.org/10.1038/clpt.1986.10

    Article  CAS  PubMed  Google Scholar 

  • Madya AP, Sutriyo (2015) Gel composition used for manufacturing gel-shaped product as coagulant of dead skin cells protein, contains coffee leaf powder, triethanolamine, carbomer 940, sodium laureth sulfate, cocamidopropyl betaine and methyl paraben. Indonesia Patent ID-201606611-A

  • Magalhães STV, Fernandes FL, Demuner AJ, Picanço MC, Guedes RNC (2010) Leaf alkaloids, phenolics, and coffee resistance to the leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). J Econ Entomol 103:1438–1443. https://doi.org/10.1603/EC09362

    Article  CAS  PubMed  Google Scholar 

  • Martinko K (2015) Coffee leaf tea is the hottest new beverage. https://www.treehugger.com/green-food/coffee-leaf-tea-hottest-new-beverage.html. Accessed 10 Oct 2020

  • Martins SCV, Araújo WL, Tohge T, Fernie AR, DaMatta FM (2014) In high-light-acclimated coffee plants the metabolic machinery is adjusted to avoid oxidative stress rather than to benefit from extra light enhancement in photosynthetic yield. PLoS ONE 9:1–11. https://doi.org/10.1371/journal.pone.0094862

    Article  CAS  Google Scholar 

  • Maurel JC, Chapuis JM, Mongold JJ, Saenz C (1995a) Sitosterol- and acylglycerol-based organometallic complexes, and pharmaceutical compositions and diet products containing same. World Patent WO-9623811-A1

  • Maurel JC, Chapuis JM, Mongold JJ, Saenz C (1995b) Sitosterol and acyl-glycerol-based complexes contg. bio-catalytic metal. France Patent FR-2729956-A1

  • Maurel JC, Chapuis JM, Mongold JJ, Jouy N (1996) Diglyceride and sterol based organometallic complexes and pharmaceutical compositions and dietetic products containing them. US Patent US-6129924-A

  • Maurel JC (2004) Reverse micelles as well as the therapeutic use thereof based on phytosterols and acylglycerols. JP-4954079-B2

  • Medeiros FCL, Resende MLV, Medeiros FHV, Zhang HM, Paré PW (2009) Defense gene expression induced by a coffee-leaf extract formulation in tomato. Physiol Mol Plant Pathol 74:175–183. https://doi.org/10.1016/j.pmpp.2009.11.004

    Article  CAS  Google Scholar 

  • Monaco LC, Sondahl MR, Carvalho A, Crocomo OJ, Sharp WR (1977) Applications of tissue cultures in the improvement of coffee. In: Reinert J, Bajaj YPS (eds) Applied and fundamental aspects of plant cell tissue and organ culture. Springer, Berlin, pp 109–129

    Google Scholar 

  • Mondolot L, La Fisca P, Buatois B, Talansier E, De Kochko A, Campa C (2006) Evolution in caffeoylquinic acid content and histolocalization during Coffea canephora leaf development. Ann Bot 98:33–40. https://doi.org/10.1093/aob/mcl080

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Monteiro Â, Colomban S, Azinheira HG, Guerra-Guimarães L, Do Céu Silva M, Navarini L, Resmini M (2020) Dietary antioxidants in coffee leaves: impact of botanical origin and maturity on chlorogenic acids and xanthones. Antioxidants 9:6. https://doi.org/10.3390/antiox9010006

    Article  CAS  Google Scholar 

  • Montis A, Souard F, Delporte C, Stoffelen P, Stévigny C, Van Antwerpen P (2021) Coffee leaves: an upcoming novel food? Planta Med 87:949–963. https://doi.org/10.1055/a-1533-0021

    Article  CAS  PubMed  Google Scholar 

  • Murata K, Yasuda H (1997) Anti-helicobacter pylori and food and drink for anti-gastritis, and gastric and duodenal ulcer, containing the same. Japan patent JP-H111429-A

  • Murthy PS, Naidu MM (2012) Sustainable management of coffee industry by-products and value addition—a review. Resour Conserv Recycl 66:45–58

    Article  Google Scholar 

  • Mussatto SI, Carneiro LM, Silva JPA, Roberto IC, Teixeira JA (2011) A study on chemical constituents and sugars extraction from spent coffee grounds. Carbohydr Polym 83:368–374. https://doi.org/10.1016/j.carbpol.2010.07.063

    Article  CAS  Google Scholar 

  • Nabais JMV, Nunes P, Carrott PJM, Ribeiro Carrott MML, García AM, Díaz-Díez MA (2008) Production of activated carbons from coffee endocarp by CO2 and steam activation. Fuel Process Technol 89:262–268. https://doi.org/10.1016/j.fuproc.2007.11.030

    Article  CAS  Google Scholar 

  • Nagasampagi BA, Rowe JW, Simpson R, Goad LJ (1971) Sterols of coffee. Phytochemistry 10:1101–1107. https://doi.org/10.1016/S0031-9422(00)89946-X

    Article  CAS  Google Scholar 

  • Naidoo N, Chen C, Rebello SA, Speer K, Tai ES, Lee J, Buchmann S, Koelling-Speer I, Van Dam RM (2011) Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study. Nutr J 10:1–10. https://doi.org/10.1186/1475-2891-10-48

    Article  CAS  Google Scholar 

  • Naidu R (2003a) The coffee plant. In: Coffee guide, 7th edn. Coffee Board of India, pp 7–10

  • Naidu R (2003b) Soil and climatic requirements. In: Coffee guide, 7th edn. Coffee Board of India, pp 24–25

  • Naidu R (2003c) Coffee physiology. In: Coffee guide, 7th edn. Coffee Board of India, pp 54–64

  • Nakagawa K, Ono H, Yamamoto H (2003) Lipase inhibitor. Japan Patent JP-2005053891-A

  • Neuwinger HD (2000) African traditional medicine: a dictionary of plant use and applications with supplement: search system for diseases. Medpharm Scientific Publishers, Stuttgart

    Google Scholar 

  • Ngamsuk S, Huang TC, Hsu JL (2019) Determination of phenolic compounds, procyanidins, and antioxidant activity in processed Coffea arabica L. leaves. Foods 8:1–13. https://doi.org/10.3390/foods8090389

    Article  CAS  Google Scholar 

  • Novita R, Kasim A, Anggraini T, Putra DP (2018) Kahwa daun: traditional knowledge of a coffee leaf herbal tea from West Sumatera, Indonesia. J Ethn Foods 5:286–291. https://doi.org/10.1016/j.jef.2018.11.005

    Article  Google Scholar 

  • Patay ÉB, Bencsik T, Papp N (2016a) Phytochemical overview and medicinal importance of Coffea species from the past until now. Asian Pac J Trop Med 9:1127–1135. https://doi.org/10.1016/j.apjtm.2016.11.008

    Article  CAS  PubMed  Google Scholar 

  • Patay ÉB, Németh T, Németh TS, Filep R, Vlase L, Papp N (2016b) Histological and phytochemical studies of Coffea benghalensis B. Heyne ex Schult., compared with Coffea arabica L. Farmacia 64:125–130

    CAS  Google Scholar 

  • Patay EB, Fritea L, Antonescu A, Sobjanschi L (2017) Coffea arabica: a plant with rich content in caffeine. In: Latosinska JN (ed) The question of caffeine. IntechOpen. https://doi.org/10.5772/intechopen.68149. https://www.intechopen.com/books/the-questionofcaffeine/coffea-arabica-a-plant-with-rich-content-in-caffeine. Accessed 14 Apr 2021

  • Pompelli MF, Martins SCV, Antunes WC, Chaves ARM, DaMatta FM (2010) Photosynthesis and photoprotection in coffee leaves is affected by nitrogen and light availabilities in winter conditions. J Plant Physiol 167:1052–1060. https://doi.org/10.1016/j.jplph.2010.03.001

    Article  CAS  PubMed  Google Scholar 

  • Preedy VR (2014) Coffee in health and disease prevention. Academic Press, New York

    Google Scholar 

  • Ragot P, Barat L, Rousseau C, Pons E (2014) Reconstituted plant material and its use for packaging, wrapping and food appliances. US Patent US-20170174404A1

  • Ratanamarno S, Surbkar S (2017) Caffeine and catechins in fresh coffee leaf (Coffea arabica) and coffee leaf tea. Maejo Int J Sci Technol 11:211

    CAS  Google Scholar 

  • Rio MJD, Wiebe JC, Lopez-Rios L, Vega-Morales T, Perez-Machin R, Sanchez-Rodriguez A, Mateos C, Gericke NP (2016) Compositions for enhancing brain activity. US-2018021397-A1

  • Ross IA (2005) Medicinal plants of the world. Human Press, New Jersey

    Google Scholar 

  • Rudkowska I, AbuMweis SS, Jones PJH, Nicolle C (2008) Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. J Am Coll Nutr 27:588–595. https://doi.org/10.1080/07315724.2008.10719742

    Article  CAS  PubMed  Google Scholar 

  • Ryu DC (1991) Tea pack of mixed tea. Japan Patent JP-H0743985-U

  • Sagawa H, Yukajin K, Onogi H, Kobayashi E, Li T, Nishimura K (2000) Therapeutic agents. China Patent CN-100457124- C

  • Salgado PR, Favarin JL, Leandro RA, De Lima Filho OF (2008) Total phenol concentrations in coffee tree leaves during fruit development. Sci Agric 65:354–359. https://doi.org/10.1590/S0103-90162008000400005

    Article  CAS  Google Scholar 

  • Sánchez Gómez C, Suaza Montalvo A, Caro Parrado M, Sánchez Sáenz C (2018) Phenolic content analysis of coffee leaves subjected to htst and convective drying. Rev UDCA Actual Divulg Científica 21:81–88. https://doi.org/10.31910/rudca.v21.n1.2018.665

    Article  Google Scholar 

  • Segheto L, Santos BCS, Werneck AFL, Vilela FMP, de Sousa OV, Rodarte MP (2018) Antioxidant extracts of coffee leaves and its active ingredient 5-caffeoylquinic acid reduce chemically-induced inflammation in mice. Ind Crops Prod 126:48–57. https://doi.org/10.1016/j.indcrop.2018.09.027

    Article  CAS  Google Scholar 

  • Shan Y (2015) Making method of coffee leaf tea. China Patent CN- 104719522-A

  • Smith RF (1985) A history of coffee. In: Clifford MN, Wilson KC (eds) Coffee, botany, biochemistry and production of coffee beans and beverage. Croom Helm, London, pp 48–97

    Google Scholar 

  • Souard F, Delporte C, Stoffelen P, Thévenot EA, Noret N, Dauvergne B, Kauffmann JM, Van Antwerpen P, Stévigny C (2018) Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS. Food Chem 245:603–612. https://doi.org/10.1016/j.foodchem.2017.10.022

    Article  CAS  PubMed  Google Scholar 

  • Steffan W, Duffin-Maxwell K, Bradbury A (2006) Polyphenol rich extract from plant material. EP-1913821-A1

  • Sudantha IM (2011) Producing bio-activator biofungiside tablet formulation by preparing coffee leaves substrate, preparing clay/clay, mixing the substrate with fine clay, refining, preparing fungus isolates. Indonesia Patent ID-201301774-A

  • Tabuti JRS, Kukunda CB, Waako PJ (2010) Medicinal plants used by traditional medicine practitioners in the treatment of tuberculosis and related ailments in Uganda. J Ethnopharmacol 127:130–136. https://doi.org/10.1016/j.jep.2009.09.035

    Article  PubMed  Google Scholar 

  • Takagaki K, Tsuzaki S (2000) Healthy tea and healthy drink and method of manufacturing the same. Japan Patent JP-2002065227-A

  • Talamond P, Mondolot L, Gargadennec A, de Kochko A, Hamon S, Fruchier A, Campa C (2008) First report on mangiferin (C-glucosyl-xanthone) isolated from leaves of a wild coffee plant, Coffea pseudozanguebariae (Rubiaceae). Acta Bot Gall 155:513–519. https://doi.org/10.1080/12538078.2008.10516130

    Article  CAS  Google Scholar 

  • Teruel EB (2006) Novel tobacco substitute. US Patent US-2008017208- A1

  • Toshimitsu, Hattori K, Takagaki S (1999) Food using gamma-aminobutyric acid-enriched cruciferous plant. European Patent EP- 1082911-A2

  • Trevisan MTS, Farias de Almeida R, Soto G, De Melo Virginio Filho E, Ulrich CM, Owen RW (2016) Quantitation by HPLC-UV of mangiferin and isomangiferin in coffee (Coffea arabica) leaves from Brazil and Costa Rica after solvent extraction and infusion. Food Anal Methods 9:2649–2655. https://doi.org/10.1007/s12161-016-0457-y

    Article  Google Scholar 

  • Ucc Ueshima Kohi Kk (1997) Deodoriser for hospital beds-contains adsorption agent e.g. dried coffee leaves or tea waste. Japan Patent JP-10314286-A

  • Waller GR, Jurzyste M, Karns TKB, Geno PW (1991) Isolation and characterization of ursolic acid from Coffea arabica L. (coffee) leaves. Colloque Scientifique International Sur Le Cafe 14:245–247

    Google Scholar 

  • Wang H (2017a) External medicine for treating skin disease. China Patent CN-107320654-A

  • Wang S (2017b) Vehicle perfume useful for preventing sleep comprises lavender, Pelargonium odoratissimum, plum blossom, lily, Michelia, Laggera pterodonta, coffee leaf, ethanol, plant extracts, citric acid, folic acid and sodium chloride. China Patent CN-107998268-A

  • Widyastuti N, Anjani G, Almira VG, Putri SE, Pratiwi AR (2020a) Effects of the administration of brewed robusta coffee leaves on total antioxidant status in rats with high-fat, high-fructose diet-induced metabolic syndrome. Potravinarstvo 14:258–263

    Article  Google Scholar 

  • Widyastuti N, Anjani G, Gustin Almira V, Eka Putri S, Rica Pratiwi A, Prawira-Atmaja MI (2020b) The effect of brewed robusta coffee leaves on insulin levels and HOMA-IR index in metabolic syndrome rats. Rom J Diabetes Nutr Metab Dis 27:16–24. https://doi.org/10.46389/rjd-2020-1004

    Article  Google Scholar 

  • Wintgens JN (2004) Coffee: growing, processing, sustainable production. A guidebook for growers, processors, traders, and researchers. WILEY-VCH Verlag GmbH & Co. KGaA

  • Woldesenebet A (2015) School of Graduate Studies College of Natural Sciences Centre for Food Science and Nutrition Nutritional composition , phytochemical screening , processing methods and Sensory attributes of a brew made from infusions of matured leaves of Arabica coffee tr. Cent. Food Sci. Nutr, Addis Ababa Univ

  • Xu H (2003) Cigarette with coffee flavor and its preparing method. China Patent CN 1206948-C

  • Ye H (2014) Feed for promoting growth and development of broilers and preparation method thereof. China Patent CN-104431535-A

  • Zhang H, Ling X, Bai X, Guo T, Li J (2014) Method for making granular coffee leaf tea. China Patent CN-105192194-A

  • Zhang Z, Rao J, Dai J, Wang J, You H (2016) Preparation method of coffee leaf fermented tea. CN-105831330-A

  • Zheng XQ, Nagai C, Ashihara H (2004) Pyridine nucleotide cycle and trigonelline (N-methylnicotinic acid) synthesis in developing leaves and fruits of Coffea arabica. Physiol Plant 122:404–411. https://doi.org/10.1111/j.1399-3054.2004.00422.x

    Article  CAS  Google Scholar 

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Acknowledgements

Authors thank the Science and Engineering research Board (SERB), Ministry of Food Processing, Government of India, Grant no. Q-11/15/2019-R&D for funding the project. Miss. Siddhi Patil acknowledges Department of Biotechnology (DBT), New Delhi, for the award of Research Fellowship.

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Correspondence to Pushpa S. Murthy.

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Patil, S., Vedashree, M. & Murthy, P.S. Valorization of coffee leaves as a potential agri-food resource: bio-active compounds, applications and future prospective. Planta 255, 67 (2022). https://doi.org/10.1007/s00425-022-03846-x

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