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Phytochemicals and Biological Activities of Asplenium ceterach

  • Living reference work entry
  • First Online:
Bioactive Compounds in Bryophytes and Pteridophytes

Part of the book series: Reference Series in Phytochemistry ((RSP))

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Abstract

Asplenium ceterach L. (family Aspleniaceae) is a perennial herbaceous fern. The lower surface of its fronds is covered with scales, which over time mature to a rusty color, giving the plant a characteristic appearance, hence the common name “rustyback” fern. It inhabits almost all of Europe, including the Mediterranean region, and Central Asia to the Himalayas, usually occurring in cracks in rocks. Rustyback fern is belonging to resurrection plants due to its ability to withstand desiccation and consequently completely recover after rehydration. It is thought that high concentrations of phenolic acids (mainly chlorogenic acid and caffeic acid) enable A. ceterach to reduce the damage of reactive oxygen species formed during dehydration. In addition to phenolic acids, the presence of other phenolic compounds is detected in A. ceterach including flavonoids, tannins, coumarins, and quinones. Phytochemical studies have shown that these phenolic compounds are mainly found in sporophytes of rustyback fern, while A. ceterach gametophyte is characterized predominantly by xanthones, primarily mangiferin and its glycoside. Additionally, rustyback fern represents a rich source of different volatile organic compounds, mainly lipid derivatives. Owing to the presence of various bioactive metabolites, it is not surprising that A. ceterach has long been known for its healing properties, and numerous studies have proven its various biological activities, including antimicrobial, antioxidant, cytotoxic, anticancer, diuretic, as well as anti-inflammatory properties.

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Abbreviations

ABTS:

2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay

AE:

Aqueous extract

ALP:

Alkaline phosphatase

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

BHA:

Butylated hydroxyanisole

BHT:

Butylated hydroxytoluene

CAT:

Catalase

CC:

Column chromatography

COD:

Calcium oxalate dyhydrate

COM:

Calcium oxalate monohydrate

DdH2O:

Deionized water

DPPH:

1,1-diphenyl-2-picrylhydrazyl

DW:

Dry weight

EPR:

Electron paramagnetic resonance

Et2O:

Diethyl ether

EtOAc:

Ethyl acetate

EtOH:

Ethanol

FAs:

Fatty acids

FRAP:

Ferric reducing antioxidant power assay

FW:

Fresh weight

G:

Gametophyte

GAE:

Gallic acid equivalent

GC-MS:

Gas chromatography-mass spectrometry

HDL:

High-density lipoprotein

HPLC-DAD:

High-performance liquid chromatography with diode array detection

HS GC-MS:

Headspace gas chromatography-mass spectrometry

LDL:

Low-density lipoprotein

MeOH:

Methanol

MPLC:

Medium pressure liquid chromatography

N-BuOH:

Butanol

ORAC:

Oxygen radical absorbance capacity assay

PC:

Paper chromatography

PTR-MS:

Proton transfer reaction-mass spectrometry

PUFAs:

Polyunsaturated fatty acids

QE:

Quercetin equivalent

RBC:

Red blood cell count

ROS:

Reactive oxygen species

S:

Sporophyte

SEM:

Scanning electron microscopy

SOD:

Superoxide dismutase

STZ:

Streptozotocin

TE:

Trolox equivalent

TEMPONE:

2,2,6,6-tetramethyl-4-oxo-piperidin-1-oxyl

TF:

Total flavonoid content

TLC:

Thin layer chromatography

TPC:

Total phenolics content

UHPLC/HESI-MS2:

Ultra-high performance liquid chromatography/heated electrospray ionization mass spectrometry

UHPLC-DAD/HESI-MS2:

Ultra-high performance liquid chromatography-diode array detection/heated electrospray ionization mass spectrometry

UV:

Ultraviolet

UVS:

Ultraviolet spectroscopy

VLC:

Vacuum liquid chromatography

VOCs:

Volatile organic compounds

WBC:

White blood cell count

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Acknowledgments

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant numbers OI173024, 451-03-9/2021-14/200007, and 451-03-68/2022-14/200007. The authors would like to thank Dr. Uroš Gašić (University of Belgrade, Serbia) for preparing chemical structures.

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  1. Institute for Biological Research “Siniša Stanković”-National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia

    Suzana Živković, Milica Milutinović & Marijana Skorić

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  1. Suzana Živković
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Correspondence to Suzana Živković .

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  1. Department of Botany, Karnatak University, Dharwad, Karnataka, India

    Hosakatte Niranjana Murthy

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Živković, S., Milutinović, M., Skorić, M. (2022). Phytochemicals and Biological Activities of Asplenium ceterach. In: Murthy, H.N. (eds) Bioactive Compounds in Bryophytes and Pteridophytes. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-97415-2_19-1

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  • DOI: https://doi.org/10.1007/978-3-030-97415-2_19-1

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